Flashman Research Group

Flashman Group 2014

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Latest Publications

The plant cysteine oxidases from Arabidopsis thaliana are kinetically tailored to act as oxygen sensors. White MD, Kamps JJAG, East S, Taylor Kearney LJ, Flashman E. J Biol Chem 2018 Jul; 293: 11786-11795. doi:10.1074/jbc.RA118.003496.
YcfDrm is a thermophilic oxygen-dependent ribosomal protein uL16 oxygenase Sekirnik R, Wilkins SE, Bush J, Tarhonskaya H, Munzel M, Hussein A, Flashman E, Mohammed S, McDonough MA, Loenarz C, Schofield CJ. Extremophiles 2018 May; 22: 553-562.
Lysine-241 has a role in coupling 2OG turnover with substrate oxidation during KDM4-catalysed histone demethylation. Hancock RL, Abboud MI, Smart TJ, Flashman E, Kawamura A, Schofield CJ, Hopkinson RJ. Chembiochem 2018 May; 19: 917-921.
Ribonucleotide reductase requires subunit switching in hypoxia to maintain DNA replication. Foskolou IP, Jorgensen C, Leszczynska KB, Olcina MM, Tarhonskaya H, Haisma B, D'Angiolella V, Myers WK, Domene C, Flashman E, Hammond EM. Mol Cell. 2017 Apr; 66: 206-220.
Plant cysteine oxidases are dioxygenases that directly enable arginyl transferase-catalysed arginylation of N-end rule targets. White MD, Klecker M, Hopkinson RJ, Weits DA, Mueller C, Naumann C, O'Neill R, Wickens J, Yang J, Brooks-Bartlett JC, Garman EF, Grossmann TN, Dissmeyer N, Flashman E. Nat Commun. 2017 Mar; 8: 14690.